CyAL-5 2-Deoxyglucose
Product Description
CyAL-5 2-deoxyglucose (CyAl-5 2-DG) is a fluorescent imaging agent designed to target a wide spectrum of cancers such as breast, glioblastoma, colon and prostate in vitro as well as in vivo. 2-DG is a glucose analog that utilizes the GLUT transporters for entry into the cell. One of the hallmarks of many cancer cells is an elevated uptake of glucose. Numerous fluorophores, including 800CW [1] and 2-NBDG [2] have been used to label 2-DG for tumor detection. FDG has been used extensively in PET imaging for diagnosis and tumor response monitoring in various types of cancer [3,4].
References
- [1] Kovar JL,Volcheck W, Olive DM, Simpson MA (2007). Abstract #5527, Poster presentation, AACR Annual Meeting.
- [2] Lloyd PG, Hardin CD, Sturek M (1999). Physiol Res 48:401-410.
- [3] Hicks RJ, Wahl RL (2010). PET diagnosis and response monitoring in oncology, Molecular Imaging, Principles and
Practice, p875-895.
- [4] Mankoff DA (2010). PET imaging in cancer clinical trials, Molecular Imaging, Principles and Practice, p1179-1191.
| Catalog # |
Product Name |
Size |
Price (USD) |
| DG-1001 |
CyAL-5 2DG
data sheet |
125 nmol |
199.00 |
The recommended individual dose per mouse will range from 10-20 nmol, depending upon tumor type, size and location. Each tube contains 125 nmol of CyAL-5 2-DG optical probe.
Storage and HandlingUpon receipt, store at -20°C prior to reconstitution. Reconstituted material should be used within
two weeks.
CyAL-5 is sold under an exclusive license from Harvard Medical School and Massachusetts General Hospital.
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CyAL-5 2-Deoxyglucose
