Recent Tc-99m Glucarate Publications   Yaoito H, Uehara T, Brownell AL, Rabito CA, Ahmad M, Khaw BA, Fischman AJ, Strauss HW. (1991) Localization of 99mTc-Glucarate in zones of acute cerebral injury. J Nucl Med 32:272-278. Orlandi C, Crane PD, Edwards DS, Platts SH, Bernard L, Lazewatsky J, Thoolen MJ. (1991) Early scintigraphic detection of experimental myocardial infarction in dogs with technetium-99m-glucaric acid. J Nucl Med 32:263-268. Willerson JT. (1991) Detection of acute myocardial infarcts by infarct-avid imaging. J Nucl Med 32:269-271. Ohtani H, Callahan RJ, Khaw BA, Fischman AJ, Wilkinson RA, Strauss HW. (1992) Comparison of technetium-99m-glucarate and thallium-201 for the identification of acute myocardial infarction in rats. J Nucl Med 33:1988-1993. Pak KY, Nedelman MA, Tam SH, Wilson E, Daddona PE. (1992) Labeling and stability antibody fragments by a direct 99mTc-labeling method. Nucl Med Bio 19:669-677. Pak KY, Nedelman MA, Kanke M, Khaw BA, Mattis JA, Strauss HI. (1992) An Instant kit method for labeling antimyosin fab’ with technetium-99m: Evaluation in an experimental Myocardial Model. J Nucl Med 33:144-149. Yaoita H, Fischman AJ, Wilkinson R, Khaw BA, Juweid M, Strauss HW. (1993) Distribution of deoxyglucose and technetium-99m-glucarate in the acutely ischemic myocardium. J Nucl Med 34:1303-1308. Ballinger JR, Cowan DSM, Boxen I, Zhang ZM, Rauth M. (1993) Effect of hypoxia on the accumulation of technetium-99m-glucarate and technetium-99m-gluconate by Chinese Hamster ovary cells in vitro. J Nucl Med 34:242-245. Ballinger JR, Proulx A, Ruddy TD. (1991) Stable Kit Formulation of technetium-99m Glucarate. Appl. Radial Isot 42:405-406. Khaw BA, Narula J. (1995) What is new in infarct imaging? American Society of Nucl Cardiol Newsletter 2:14. Khaw BA. (1996) Early detection of myocardial injury and infarction. J Nucl Med 43rd Annual Meeting Handout Book 1-4. Pak KY, Narula J, Petrov A, Imran V, Mariani G, Villa G, Strauss HW, Khaw BA. (1997) AMISCANTM (Tc-99m glucarate)-A novel delineator of acute myocardial infarction: From laboratory to clinic. Shenzhen Medical J 10(2):22-24. Molea N, Lazzeri E, Bodeli L, DiLuca L, Bacciardi D, Khaw BA, et al. (1997) Biodistribution pharmacokinetics and dosimetry 99mTc-glucaric acid in humans. In: Bergman H, Droiss A, Sinizinger H, eds. Radioactive Isotopes in Clinical Medicine and Res. XXII. Basel, Switzerland: Birkhauser Verlag 359-364. Narula J, Petrov A, Pak KY, Lister BC, Khaw BA. (1997) Very early noninvasive detection of acute experimental non-reperfused myocardial infarction with technetium-99m-labeled glucarate. Circulation 95:1577-1584. Petrov A, Narula J, Nakazawa A, Pak KY, Khaw BA. (1997) Targeting human breast tumor in xeno-grafted SCID mice withtechnetium-99m-glucarate. Nucl Med Commun 18:241-251. Beanlands RSB, Ruddy TD, Bielawski L, Johansen H, Pasler A, Masika M. (1997) Differentiation of myocardial ischemia and necrosis by technetium-99m-glucaric acid kinetics. J Nucl Cardiol 4:274-282. Gerson MC, McGordon AJ. (1997) Technetium-99m-glucarate: What will be its clinical role? Editorial J Nucl Cardiol 4:336-340. Khaw BA, Nakazawa A, O’Donnell SM, Pak KY, Narula J. (1997) Avidity of technetium-99m glucarate for the necrotic myocardium: In vivo and in vitro assessment. J Nucl Cardiol 4:283-290. Khaw BA, Narula J. (1998) New approaches to infarct-avid imaging. New Developments in Cardiac Nuclear Imaging. (From: Iskandrian AE and Verani MS, (eds) Armonk, NY: Futura Publishing Company, Inc) 171-202. Khaw BA. (1998) New methods in nuclear cardiac imaging infarct avid agents. American Society of Nucl Cardiol Annual Meeting Handout Book 1-8. Botvinick E. (1998) Hot spot imaging. J Nucl Cardiol March/April. Khaw BA. (1999) New infarct avid imaging agents. Society Nucl Med 46th Annual Meeting Handout Book. Taillefer R, Tamaki N. (1999) New radiotracers in cardiac imaging: Principals and applications. Stamford, CN: Appleton & Lange 197-209. Mariani G, Villa G, Rossettin P, Spallarossa B, P Gian, Paolo G, Brunelli, Pak KY, Khaw BA, Strauss HW. (1999) Detection of acute myocardial infarction by 99mTc-labeled D-Glucaric acid imaging in patients with acute chest pain. J Nucl Med 40:1832-1839. Johnson L, Schofield L, Mastrofrancesco, BS Donahay, T Farb, Khaw BA. (2000) Technetium-99m glucarate uptake in a swine model of limited flow plus increased demand. J Nucl Cardiol 7:590-598. Wiersema AM, Oyen WJG, Dirksen R, Verhofstad AAJ, Corstenst FHM, van der Vilet JA. (2000) Early assessment of skeletal muscle damage after ischaemia-reperfusion injury using Tc-99m-glucarate. Cardiovascular Surgery 8:186-191. Arteaga de Murphy C, Ferro-Flores G, Villanueva-Sanchez O, Murphy-Stack E, Pedraza-Lopez M, Melendez-Alafort L, Molina-Trinidad E. (2002) 99mTc-glucarate for detection of isoproterenol-induced myocardial infarction in rats. International J of Pharmaceutics 233:29-34. Khaw BA, Silva Jose Da, Petrov, Artiom, Hartner, William. (2002) Indium-111 antimyosin and Tc-99m glucaric acid for noninvasive identification of oncotic and apoptotic myocardial necrosis. J Nucl Cardiol 9:471-481. Okada DR, Johnson G, Liu Z, Hocherman SD, Khaw BA, Pak KY, Okada RD (2002) Myocardial kinetics of 99mTc-Glucarate in low-flow, hypoxia and aglycemia. J Nucl Cardiol 10:168-176. Okada DR, Johnson G, Liu Z, Hocherman SD, Khaw BA, Okada RD, (2004) Early Detection of Infarct in Reperfused Canine Myocardium Using 99mTc-Glucarate. J Nucl Med 45:655-664. Ballinger JR, Hsue V, Rauth, AM. (2003) Accumulation of technetium-99m glucarate: in vitro cell cultures and in vivo tumour models. Nucl Med Commun 24:597-606. Okada DR, Johnson G III, Hocherman SD, Khaw BA, Pak KY, Okada RD. (2003) Myocardial kinetics of Tc-99m glucarate in low flow, hypoxia, and aglycemia. J Nucl Cardiol 10:168-176. Liu Z, Barrett HH, Stevenson G, Kastis G, Bettan M, Furenlid LR, Wilson DW, Pak KY. (2004) High-Resolution Imaging with 99mTc-Glucarate for Assessing Myocardial Injury in Rat Heart Models Exposed to Different Durations of Ischemia with Reperfusion. J Nucl Med 45:1251-1259. Liu Z, Stevenson GD, Barrett HH, Kastis G, Bettan M, Furenlid LR, Wilson DW, Woolfenden JM, Pak KY. (2004) 99mTc-glucarate high-resolution imaging of drug sensitive and drug resistant human breast cancer xenografts in SCID mice. Nucl Med Commu 25:711-720. Beju B, Khaw BA, Pak KY, Okada RD, Warren WK. (1999) Tc-99m glucarate can detect myocardial necrosis early after injury due to severe ischemia with reperfusion. J Nucl Med 40:180P. Johnson G, Liu Z, Hart CL, Eaton MW, Pak KY, Khaw BA, Okada RD. (2000) Selective detection of infarct in myocardium with residual ischemia using 99mTc-glucartate. J Nucl Med 41:171P. Khaw BA, Petrov A, Narula J, Pak KY. (1999) Can the uptake ratios of Tc-99m glucarate in acute myocardial infarction be affected by the glycemic state ? Biodistribution in fasted, non-fasted and insulin-injected mice. J Nucl Med;40: 186P. Rammohan R, Petrov A, Vural I, et al. (1996) Subnuclear Localization of 99mTc Glucarate in Necrotic Myocardium. J Nucl Med 37:175P. Vural I, Narula J, Petrov A, Pak KY, Khaw BA. (1995) Can Tc-99m Glucarate also recognize Diffuse Myocardial Necrosis? J Nucl Med 36:47P.