Meet the Team





Chris Pak

Koon Yan "Chris" Pak, Ph.D.

Co-Founder and Chief Executive Officer

Dr. Pak has been in the Biotechnology field for over two decades. He was formerly associated with Centocor, a top-tier biopharmaceutical company, now a subsidiary of Johnson and Johnson. Dr. Pak has served as the President of the Chinese American Society of Nuclear Medicine, the Vice
Chair of the Global Monte Jade Science and Technology Association, and the Chairman of the Chinese Entrepreneur Association which he co-founded. Currently, he is a board member of Monte Jade Science and Technology Association of Mid-Atlantic. Dr. Pak holds numerous patents and has published more than sixty articles covering the use of antibodies and small molecules for cancer and cardiovascular diseases. Dr. Pak's recent awards include the 2014 Lifetime Achievement Award from the Chinese American Society of Nuclear Medicine and Molecular Imaging, State University of New York at Plattsburgh Distinguished Visiting Alumnus Award, SUNY Honor Roll of Alumni, Ben Franklin Emerging Business Award and Outstanding Asian American Business Award.




Jeffrey A. Mattis

Jeffrey A. Mattis, Ph.D.

Senior Vice President of Scientific & Regulatory Affairs

Dr. Mattis is a biopharmaceutical executive with more than 30 years experience in the technical development of biopharmaceuticals. Dr. Mattis previously served as Vice President of Pharmaceutical Development for Centocor. Dr. Mattis was instrumental in the technical development of several biopharmaceuticals approved for the US and multinational markets. These include ReoPro®, an anti-platelet drug for use in coronary angioplasty; Remicade®, a drug for treatment of Crohn’s disease and rheumatoid arthritis; and Myoscint®, a cardiac imaging agent.




Brian Gray

Brian D. Gray, Ph.D.

Vice President of Research

Dr. Gray earned a Ph.D. in Organic Chemistry in 1983 from the University of Dundee, Scotland, and carried out post-doctoral research involving the synthesis of complex organic molecules first initially at Oregon State University and then at SmithKline Beckman. In 1988 he helped co-found Zynaxis, Inc., a biotechnology company, with colleagues from SmithKline, and rose to the position of Director of Medicinal Chemistry. From 1997 until May 2007 he served as V.P. of Chemical Research for PTI Research, Inc. (PTIR), a firm that provides contract and custom chemistry services for life science and pharmaceutical researchers in academia and industry, specializing in the synthesis of heterocyclic organics, bioconjugates, and compounds requiring complex multistep syntheses. He was also the PI on several NIH grants while at PTIR and was responsible for the design and development of novel research reagents for neuronal tract tracing (NeuroVue® dyes) and cell tracking (CellVue® dyes) now being manufactured and sold by MTTI. Dr Gray has more than 25 years experience in the design and synthesis of novel compounds for biomedical research, diagnostics and drug delivery applications, with special expertise in the chemistry of fluorescent dyes and lipophilic agents.




Michael Silvon

Michael Silvon, Ph.D., MBA

Senior Vice President of Business Development

Dr. Silvon is a seasoned CRO operations, strategic planning and M&A Executive. He has created, fixed and grown multiple high science, heavily regulated life science services businesses. Dr. Silvon is experienced in driving profitable, pragmatic molecular biology, microbiology, virology, synthesis, bioanalysis, preclinical and clinical testing lab operations.

Dr. Silvon has developed strategic plans for multiple employers and consulting clients and orchestrated 6 acquisitions from planning to closing for four firms, all preceded by screening and due diligence against strategic selection criteria. All included detailed integration plans. Attentive to critical leadership, financial, people/culture, markets and competitive technology performance drivers, Dr. Silvon ran integrated businesses for 3 of these long-term. As VP of Global Biopharmaceutical Services he grew value in microbiology lab under Charles River through improved staff efficiencies, focused QA, automation, RMM, streamlined reporting and acquisition assessment. He optimizes investor value, grounded in broad, proactive finance community relationships.




Scientific Advisors



Ban An Khaw, Ph.D.

Dr. Khaw is a leading authority in the field of cardiac imaging and new technology development. He co-developed Myoscint for myocardial infarct detection with Dr. Edgar Haber (former President of Bristol-Myers-Squibb). Dr. Khaw has been with the Harvard Medical School and the Massachusetts General Hospital, Division of Nuclear Medicine, Department of Radiology and the Cardiac Unit for almost three decades, and is currently the Director of the Center for Drug Targeting and Analysis, at the Bouve College of Pharmacy and Health Sciences at Northeastern University. Dr. Khaw is a pioneer in the application of immunological methods in the diagnosis of cardiovascular diseases, as well as being an inventor for a dozen of patents. Currently, he is on the editorial boards of Bioconjugate Chemistry and American Journal of Nuclear Cardiology.




Professor Fabian Kiessling, M.D., Ph.D.

Professor Fabian Kiessling has been head of the Institute of Experimental Molecular Imaging at the Helmholtz Center of Applied Engineering of the RWTH-University in Aachen, Germany since 2008. Dr. Kiessling’s research has focused on the development of novel probes and imaging tools for diagnosis and monitoring of disease-specific angiogenesis related processes. Professor Kiessling studied Medicine and received his Ph.D. from the University in Heidelberg. After serving as a resident in the Department of Radiology at the German Cancer Research Center (DKFZ) in Heidelberg he joined the Department of Medical Physics in Radiology as leader of the Molecular Imaging group in 2003. He completed his clinical training at the University of Heidelberg and received board certification as a Radiologist in 2007, and his Habilitation in experimental radiology in 2006. Dr. Kiessling has authored more than 200 scientific publications and book chapters, edited two books and received many research awards, including the “Emil Salzer Prize for Cancer Research” and the “Richtzenhain Prize”. Professor Kiessling serves on the Editorial board of several scientific journals including Radiology, European Radiology, American Journal of Nuclear Medicine and Molecular Imaging, Current Medicinal Chemistry, Frontiers in Bioscience and the Open Organic Chemistry Journal. He is a founding member of the European Society for Functional and Molecular Imaging in Radiology (ESMOFIR), currently treasurer of the European Society for Molecular Imaging (ESMI), a founding member of the ESMI working group “Image Guided Therapy and Drug Delivery (IGTDD) “chairman of the “Molecular Imaging” subcommittee of the European Society for Radiology (ESR) and a member of the program committee of the World Molecular Imaging Conference (WMIS).




Guiliano Mariani, M.D.

Dr. Mariani is Full Professor of Nuclear Medicine and Director of the Postgraduate Specialty School in Nuclear Medicine at the University of Pisa Medical School, and Director of the Regional Center of Nuclear Medicine of the University Hospital of Pisa, Italy. He has been in the field of Nuclear Medicine for over 35 years, initially involved in pharmacokinetic studies with radioactive tracers in humans, then in all other aspects of diagnostic and therapeutic Nuclear Medicine. His expertise has developed through several collaborations with other disciplines and with other institutions, including extended stays at the National Cancer Institute, Bethesda, MD (1974-1976), and at the Harvard Medical School, Boston, MA (1986-1990). Dr. Mariani is currently International Associate Editor of “The Journal of Nuclear Medicine,” and member of the Editorial Board of the “European Journal of Nuclear Medicine and Molecular Imaging,” “The Quarterly Journal of Nuclear Medicine,” and of other prestigious international journals. He is the current President of the Italian Study Group of RadioImmunoScintography and Radioguided Surgery and the former President of the International Association of Radiopharmacology. He has published six books and more than 180 articles in peer-reviewed journals covering virtually all aspects of diagnostic and therapeutic Nuclear Medicine, both clinical and experimental, with a major focus on molecular targeting with radioactive tracers.




H. William Strauss, M.D.

Dr. Strauss is the Clinical Director, Nuclear Medicine Service at Memorial Sloan-Kettering Cancer Center. Formerly Dr. Strauss was Professor of Radiology and Chief of Nuclear Medicine at Stanford University School of Medicine and Vice President of Bristol-Myers-Squibb from 1992 to 1994. Prior to that, Dr. Strauss was Professor at the Harvard Medical School and Massachusetts General Hospital for almost two decades. The recipient of numerous awards, his recent honors include the Distinguished Service Award of the Society of Nuclear Medicine and distinguished Johns Hopkins Nuclear Medicine Alumni Award. He has served on many national and international committees and boards such as Advisory Committee of Federal Drug Administration (1979-1987) and Medical Expert Advisory Committee on Disciplinary Matters, Board of Registration in Medicine (1988-1992). He serves on the editorial boards of the American Journal of Cardiology and Journal of Nuclear Medicine. He is the author of over 450 papers and articles and editors of several major books.




News

Posted 6/27/2017 - TumorVue Image Wins the 2017 MILabs Image of the Year Award
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Posted 12/05/2016 - MTTI announces that response of colorectal cancer to treatment can be detected as early as one day after treatment
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Posted 08/18/2016 - New milestone: 癌症治療新曙光 國衛院與泰緯生技攜手抗癌
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Posted 01/08/2016 - MTTI Receives Multimodality DPA Technology Patent
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Posted 05/15/2015 - MTTI receives expanded patent approval for 99mTc-Duramycin technology to target programmed cell death
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Posted 05/08/2015 - World news on Novel Cancer Therapeutic



Posted 05/06/2015 - MTTI announces the capability of PSVue 794 to non-invasively image arthritis
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Posted 04/22/2015 - MTTI Smith Molecular Probe on WSBT View Video




Posted 04/22/2015 - Dr. Bradley Smith speaks about the potential clinical applications of Cell-Death Imaging Agent View Video




Posted 04/18/2015 - 國家衛生研究院暨美國Molecular Targeting Technologies公司於2015美國癌症研究協會(AACR)共同發表新穎癌症治療法合作案之研發成果
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Posted 04/17/2015 - MTTI and National Health Research Institutes Present a Novel Cancer Therapeutic at 2015 AACR
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Posted 10/24/2014 - MTTI receives patent approval for technology to identify dead and dying cells in patients
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Posted 08/04/2014 - MTTI and National Health Research Institutes Have Joined Forces in Developing Novel Cancer Therapeutics
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Posted 08/04/2014 - 國 家衛生研究院暨美國 家衛生研究院暨美國 家衛生研究院暨美國 家衛生研究院暨美Molecular Targeting Molecular Targeting Molecular Targeting 公司 合作進行新穎癌症治療法之研發 合作進行新穎癌症治療法之研發 合作進行新穎癌症治療法之研發 合作進行新穎癌症治療法之研發 合
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Posted 06/13/2014 - Chris Pak received 2014 Lifetime Achievement Award from CASNMMI
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Posted 02/26/14 - Philadelphia Business Journal Recognizes MTTI for 2013 Innovation Award
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Posted 06/21/13 - Real time assessment of tumor response presentation wins the Innovation Competition
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Posted 11/28/12 - Notre Dame and MTTI Awarded Patent for Fluorescent Dye Technology
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Posted 8/2/12 - MTTI licenses Novel Targeting Agent from Medical College of Wisconsin
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Posted 5/10/11 - MTTI licenses robust NIR dye technology from Massachusetts General Hospital
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Posted 10/12/10 - Jefferson Awarded Multi-Million Dollar NIH Grant
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Posted 9/22/10- Zn_DPA Cardiac Imaging Study Wins Competition
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Posted 3/19/10 - University of Notre Dame and MTTI in Deal
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Posted 3/1/10 - Molecular Targeting Technologies, Inc. Licenses Cell Targeting Technology from the University of Notre Dame
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Posted 3/2/09 - LI-COR Sciences and MTTI Introduce CellVue® Dye Kits for Fluorescent Labeling of Cell Membranes
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Posted 8/23/08 - MTTI has B-Bridge Inc. as a distributor for Japan.
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Posted 8/22/08 - MTTI has engaged Dundee Cell Products as a distributor for Europe.
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Posted 4/22/08 - MTTI will collaborate with Bexion to develop a novel nanovesicle for molecular imaging of tumors.
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Posted 1/8/08 - MTTI and GENSEEN Partner to Develop Breast Cancer Gene Imaging Agent
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